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Postexposure vaccination massively increases the prevalence of γ-herpesvirus-specific CD8(+) T cells but confers minimal survival advantage on CD4-deficient mice

Mice that lack CD4(+) T cells remain clinically normal for more than 60 days after respiratory challenge with the murine γ-herpesvirus 68 (γHV-68), then develop symptoms of a progressive wasting disease. The γHV-68-specific CD8(+) T cells that persist in these I-A(b−/−) mice are unable to prevent co...

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Detalhes bibliográficos
Main Authors: Belz, Gabrielle T., Stevenson, Philip G., Castrucci, Maria R., Altman, John D., Doherty, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15997/
https://ncbi.nlm.nih.gov/pubmed/10694575
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