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Bim and Bad mediate imatinib-induced killing of Bcr/Abl(+) leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
Cell killing is a critical pharmacological activity of imatinib to eradicate Bcr/Abl(+) leukemias. We found that imatinib kills Bcr/Abl(+) leukemic cells by triggering the Bcl-2-regulated apoptotic pathway. Imatinib activated several proapoptotic BH3-only proteins: bim and bmf transcription was incr...
Kaydedildi:
| Asıl Yazarlar: | , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2006
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1595449/ https://ncbi.nlm.nih.gov/pubmed/16997913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606176103 |
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