Bim and Bad mediate imatinib-induced killing of Bcr/Abl(+) leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic

Cell killing is a critical pharmacological activity of imatinib to eradicate Bcr/Abl(+) leukemias. We found that imatinib kills Bcr/Abl(+) leukemic cells by triggering the Bcl-2-regulated apoptotic pathway. Imatinib activated several proapoptotic BH3-only proteins: bim and bmf transcription was incr...

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Detalhes bibliográficos
Main Authors: Kuroda, Junya, Puthalakath, Hamsa, Cragg, Mark S., Kelly, Priscilla N., Bouillet, Philippe, Huang, David C. S., Kimura, Shinya, Ottmann, Oliver G., Druker, Brian J., Villunger, Andreas, Roberts, Andrew W., Strasser, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1595449/
https://ncbi.nlm.nih.gov/pubmed/16997913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606176103
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