Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs

The transformed monocyte/macrophage cell line J774.2 undergoes apoptosis when treated for 48 h with competitive inhibitors of cyclooxygenase (COX) isoenzymes 1 and 2. Many of these nonsteroid antiinflammatory drugs (NSAIDs), but in particular diclofenac, induce during this time period a COX activity...

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Main Authors: Simmons, Daniel L., Botting, Regina M., Robertson, Philip M., Madsen, Matthew L., Vane, John R.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 1999
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC15932/
https://ncbi.nlm.nih.gov/pubmed/10077674
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