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Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs

The transformed monocyte/macrophage cell line J774.2 undergoes apoptosis when treated for 48 h with competitive inhibitors of cyclooxygenase (COX) isoenzymes 1 and 2. Many of these nonsteroid antiinflammatory drugs (NSAIDs), but in particular diclofenac, induce during this time period a COX activity...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Simmons, Daniel L., Botting, Regina M., Robertson, Philip M., Madsen, Matthew L., Vane, John R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15932/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077674/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.3275
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