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Vertebrate POT1 Restricts G-Overhang Length and Prevents Activation of a Telomeric DNA Damage Checkpoint but Is Dispensable for Overhang Protection

Although vertebrate POT1 is thought to play a role in both telomere capping and length regulation, its function has proved difficult to analyze. We therefore generated a conditional cell line that lacks wild-type POT1 but expresses an estrogen receptor-POT1 fusion. The cells grow normally in tamoxif...

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Main Authors: Churikov, Dmitri, Wei, Chao, Price, Carolyn M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2006
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592853/
https://ncbi.nlm.nih.gov/pubmed/16943437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01011-06
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