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Pot1 and cell cycle progression cooperate in telomere length regulation
Removal of the vertebrate telomere protein Pot1 results in a DNA damage response and cell cycle arrest. Here we show that loss of chicken Pot1 causes Chk1 activation, and inhibition of Chk1 signaling prevents the cell cycle arrest. However, arrest still occurs after disruption of ATM, which encodes...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516480/ https://ncbi.nlm.nih.gov/pubmed/18066078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1331 |
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