CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76

Deciphering the role of lymphocyte membrane proteins depends on dissecting the role of a protein in the steady state and on engagement with its ligand. We show that expression of CD6 in T cells limits their responsiveness but that engagement by the physiological ligand CD166 gives costimulation. Thi...

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Hlavní autoři: Hassan, Namir J., Simmonds, Stephen J., Clarkson, Nicholas G., Hanrahan, Sarah, Puklavec, Michael J., Bomb, Martine, Barclay, A. Neil, Brown, Marion H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592849/
https://ncbi.nlm.nih.gov/pubmed/16914752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00688-06
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