Hypomorphic Mutation of the TALE Gene Prep1 (pKnox1) Causes a Major Reduction of Pbx and Meis Proteins and a Pleiotropic Embryonic Phenotype

The interaction of Prep1 and Pbx homeodomain transcription factors regulates their activity, nuclear localization, and likely, function in development. To understand the in vivo role of Prep1, we have analyzed an embryonic lethal hypomorphic mutant mouse (Prep1(i)(/)(i)). Prep1(i)(/)(i) embryos die...

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Hauptverfasser: Ferretti, Elisabetta, Villaescusa, J. Carlos, Di Rosa, Patrizia, Fernandez-Diaz, Luis C., Longobardi, Elena, Mazzieri, Roberta, Miccio, Annarita, Micali, Nicola, Selleri, Licia, Ferrari, Giuliana, Blasi, Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592771/
https://ncbi.nlm.nih.gov/pubmed/16847320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00313-06
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