Hypomorphic Mutation of the TALE Gene Prep1 (pKnox1) Causes a Major Reduction of Pbx and Meis Proteins and a Pleiotropic Embryonic Phenotype

The interaction of Prep1 and Pbx homeodomain transcription factors regulates their activity, nuclear localization, and likely, function in development. To understand the in vivo role of Prep1, we have analyzed an embryonic lethal hypomorphic mutant mouse (Prep1(i)(/)(i)). Prep1(i)(/)(i) embryos die...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ferretti, Elisabetta, Villaescusa, J. Carlos, Di Rosa, Patrizia, Fernandez-Diaz, Luis C., Longobardi, Elena, Mazzieri, Roberta, Miccio, Annarita, Micali, Nicola, Selleri, Licia, Ferrari, Giuliana, Blasi, Francesco
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2006
Θέματα:
Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592771/
https://ncbi.nlm.nih.gov/pubmed/16847320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00313-06
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