Activated Polyamine Catabolism in Acute Pancreatitis : α-Methylated Polyamine Analogues Prevent Trypsinogen Activation and Pancreatitis-Associated Mortality

Polyamines are essential for normal cellular growth and function. Activation of polyamine catabolism in transgenic rats overexpressing spermidine/spermine N(1)-acetyltransferase, the key enzyme in polyamine catabolism, results in severe acute pancreatitis. Here, we investigated the role of polyamine...

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Main Authors: Hyvönen, Mervi T., Herzig, Karl-Heinz, Sinervirta, Riitta, Albrecht, Elke, Nordback, Isto, Sand, Juhani, Keinänen, Tuomo A., Vepsäläinen, Jouko, Grigorenko, Nikolay, Khomutov, Alex R., Krüger, Burkhard, Jänne, Juhani, Alhonen, Leena
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592678/
https://ncbi.nlm.nih.gov/pubmed/16400014
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