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Failure to prolyl hydroxylate hypoxia-inducible factor α phenocopies VHL inactivation in vivo
Many functions have been assigned to the von Hippel-Lindau tumor suppressor gene product (pVHL), including targeting the alpha subunits of the heterodimeric transcription factor HIF (hypoxia-inducible factor) for destruction. The binding of pVHL to HIFα requires that HIFα be hydroxylated on one of t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1589988/ https://ncbi.nlm.nih.gov/pubmed/16977322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601300 |
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