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VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation
VHL inactivation is a key oncogenic event for renal carcinomas. In normoxia, VHL suppresses HIF1a-mediated transcriptional response, which is characteristic to hypoxia. It has previously been shown that hypoxic conditions inhibit TET-dependent hydroxymethylation of cytosines and cause DNA hypermethy...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6045645/ https://ncbi.nlm.nih.gov/pubmed/30006568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28795-y |
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