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Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
Pharmacologic activation of the heterodimeric HIF transcription factor appears promising as a strategy to treat diseases, such as anemia, myocardial infarction, and stroke, in which tissue hypoxia is a prominent feature. HIF accumulation is normally linked to oxygen availability because an oxygen-de...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265460/ https://ncbi.nlm.nih.gov/pubmed/18096761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-117812 |
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