The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways

Vav is a GTP/GDP exchange factor (GEF) for members of the Rho-family of GTPases that is rapidly tyrosine-phosphorylated after engagement of the T cell receptor (TCR), suggesting that it may transduce signals from the receptor. T cells from mice made Vav-deficient by gene targeting (Vav(−/−)) fail to...

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Main Authors: Costello, Patrick S., Walters, Alice E., Mee, P. Joseph, Turner, Martin, Reynolds, Lucinda F., Prisco, Antonella, Sarner, Nitza, Zamoyska, Rose, Tybulewicz, Victor L. J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15890/
https://ncbi.nlm.nih.gov/pubmed/10077632
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