The Rho Exchange Factors Vav2 and Vav3 Favor Skin Tumor Initiation and Promotion by Engaging Extracellular Signaling Loops

The catalytic activity of GDP/GTP exchange factors (GEFs) is considered critical to maintain the typically high activity of Rho GTPases found in cancer cells. However, the large number of them has made it difficult to pinpoint those playing proactive, nonredundant roles in tumors. In this work, we h...

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Autors principals: Menacho-Márquez, Mauricio, García-Escudero, Ramón, Ojeda, Virginia, Abad, Antonio, Delgado, Pilar, Costa, Clotilde, Ruiz, Sergio, Alarcón, Balbino, Paramio, Jesús M., Bustelo, Xosé R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3720258/
https://ncbi.nlm.nih.gov/pubmed/23935450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001615
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