Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

BACKGROUND: Nuclear factor erythroid-2 related factor 2 (NRF2) is a redox-sensitive transcription factor that positively regulates the expression of genes encoding antioxidants, xenobiotic detoxification enzymes, and drug efflux pumps, and confers cytoprotection against oxidative stress and xenobiot...

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Hauptverfasser: Singh, Anju, Misra, Vikas, Thimmulappa, Rajesh K, Lee, Hannah, Ames, Stephen, Hoque, Mohammad O, Herman, James G, Baylin, Stephen B, Sidransky, David, Gabrielson, Edward, Brock, Malcolm V, Biswal, Shyam
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2006
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1584412/
https://ncbi.nlm.nih.gov/pubmed/17020408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0030420
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