Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor α and IL-18

The role of leptin was investigated in two models of T cell-mediated hepatitis: the administration of Con A or of Pseudomonas aeruginosa exotoxin A (PEA). In both models, leptin-deficient (ob/ob) mice were protected from liver damage and showed lower induction of tumor necrosis factor (TNF) α and IL...

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Bibliographic Details
Main Authors: Faggioni, Raffaella, Jones-Carson, Jessica, Reed, David A., Dinarello, Charles A., Feingold, Kenneth R., Grunfeld, Carl, Fantuzzi, Giamila
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC15807/
https://ncbi.nlm.nih.gov/pubmed/10681432
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