Rapid vascular regrowth in tumors after reversal of VEGF inhibition

Inhibitors of VEGF signaling can block angiogenesis and reduce tumor vascularity, but little is known about the reversibility of these changes after treatment ends. In the present study, regrowth of blood vessels in spontaneous RIP-Tag2 tumors and implanted Lewis lung carcinomas in mice was assessed...

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Main Authors: Mancuso, Michael R., Davis, Rachel, Norberg, Scott M., O’Brien, Shaun, Sennino, Barbara, Nakahara, Tsutomu, Yao, Virginia J., Inai, Tetsuichiro, Brooks, Peter, Freimark, Bruce, Shalinsky, David R., Hu-Lowe, Dana D., McDonald, Donald M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578604/
https://ncbi.nlm.nih.gov/pubmed/17016557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24612
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