Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling in Cancer Causes Loss of Endothelial Fenestrations, Regression of Tumor Vessels, and Appearance of Basement Membrane Ghosts

Angiogenesis inhibitors are receiving increased attention as cancer therapeutics, but little is known of the cellular effects of these inhibitors on tumor vessels. We sought to determine whether two agents, AG013736 and VEGF-Trap, that inhibit vascular endothelial growth factor (VEGF) signaling, mer...

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Main Authors: Inai, Tetsuichiro, Mancuso, Michael, Hashizume, Hiroya, Baffert, Fabienne, Haskell, Amy, Baluk, Peter, Hu-Lowe, Dana D., Shalinsky, David R., Thurston, Gavin, Yancopoulos, George D., McDonald, Donald M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2004
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618540/
https://ncbi.nlm.nih.gov/pubmed/15215160
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