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Localization of the pH Gate in Kir1.1 Channels
We used cysteine-modifying reagents to localize the pH-sensitive gate in the renal inward-rectifier K(+) channel Kir1.1a (ROMK1). Cytoplasmic-side methanethiosulfonate (MTS) reagents blocked K(+) permeation in native Kir1.1 channels, expressed in Xenopus oocytes. Replacement of three cysteines in th...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Biophysical Society
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1578472/ https://ncbi.nlm.nih.gov/pubmed/16891366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.087700 |
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