Localization of the pH Gate in Kir1.1 Channels

We used cysteine-modifying reagents to localize the pH-sensitive gate in the renal inward-rectifier K(+) channel Kir1.1a (ROMK1). Cytoplasmic-side methanethiosulfonate (MTS) reagents blocked K(+) permeation in native Kir1.1 channels, expressed in Xenopus oocytes. Replacement of three cysteines in th...

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Bibliografiske detaljer
Main Authors: Zhang, Yu-Yang, Sackin, Henry, Palmer, Lawrence G.
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2006
Fag:
Channels, Receptors, and Electrical Signaling
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578472/
https://ncbi.nlm.nih.gov/pubmed/16891366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.087700
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