Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: An integrin-binding cysteine protease

Pathogenic bacteria secrete protein toxins that weaken or disable their host, and thereby act as virulence factors. We have determined the crystal structure of streptococcal pyrogenic exotoxin B (SpeB), a cysteine protease that is a major virulence factor of the human pathogen Streptococcus pyogenes...

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Autori principali: Kagawa, Todd F., Cooney, Jakki C., Baker, Heather M., McSweeney, Sean, Liu, Mengyao, Gubba, Siddeswar, Musser, James M., Baker, Edward N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC15784/
https://ncbi.nlm.nih.gov/pubmed/10681429
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