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Crystal structure of the zymogen form of the group A Streptococcus virulence factor SpeB: An integrin-binding cysteine protease

Pathogenic bacteria secrete protein toxins that weaken or disable their host, and thereby act as virulence factors. We have determined the crystal structure of streptococcal pyrogenic exotoxin B (SpeB), a cysteine protease that is a major virulence factor of the human pathogen Streptococcus pyogenes...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kagawa, Todd F., Cooney, Jakki C., Baker, Heather M., McSweeney, Sean, Liu, Mengyao, Gubba, Siddeswar, Musser, James M., Baker, Edward N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15784/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681429/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040549997
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