Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91(phox) expression in porcine pulmonary artery endothelial cells

1. Acute respiratory distress syndrome (ARDS) is associated with increased superoxide (O(2)(•−)) formation in the pulmonary vasculature and negation of the bioavailability of nitric oxide (NO). Since NO inhibits NADPH oxidase expression through a cyclic GMP-mediated mechanism, sildenafil, a type V p...

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Main Authors: Muzaffar, Saima, Shukla, Nilima, Srivastava, Amit, Angelini, Gianni D, Jeremy, Jamie Y
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576252/
https://ncbi.nlm.nih.gov/pubmed/15980872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706305
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