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Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91(phox) expression in porcine pulmonary artery endothelial cells
1. Acute respiratory distress syndrome (ARDS) is associated with increased superoxide (O(2)(•−)) formation in the pulmonary vasculature and negation of the bioavailability of nitric oxide (NO). Since NO inhibits NADPH oxidase expression through a cyclic GMP-mediated mechanism, sildenafil, a type V p...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1576252/ https://ncbi.nlm.nih.gov/pubmed/15980872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706305 |
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