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Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation

1. Benzodiazepines (BZDs) have been used extensively for more than 40 years because of their high therapeutic index and low toxicity. Although BZDs are understood to act primarily as allosteric modulators of GABA(A) receptors, the mechanism of modulation is not well understood. 2. The applicability...

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Bibliografske podrobnosti
Main Authors: Downing, Scott S, Lee, Yan T, Farb, David H, Gibbs, Terrell T
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576208/
https://ncbi.nlm.nih.gov/pubmed/15912137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706251
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