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Docking of 1,4-Benzodiazepines in the α(1)/γ(2) GABA(A) Receptor Modulator Site
Positive allosteric modulation of the GABA(A) receptor (GABA(A)R) via the benzodiazepine recognition site is the mechanism whereby diverse chemical classes of therapeutic agents act to reduce anxiety, induce and maintain sleep, reduce seizures, and induce conscious sedation. The binding of such ther...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713131/ https://ncbi.nlm.nih.gov/pubmed/19483108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.054650 |
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