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Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors

1. Neuroprotection has been reported after either activation or blockade of the group I metabotropic glutamate receptor subtype 5 (mGluR5). However, some recent evidence suggests that protection provided by mGluR5 antagonists may reflect their ability to inhibit N-methyl-D-aspartate (NMDA) receptor...

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Main Authors: Lea, Paul M, Movsesyan, Vilen A, Faden, Alan I
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576169/
https://ncbi.nlm.nih.gov/pubmed/15821750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706219
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