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Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells
1. Sphingosine-1-phosphate (S1P) is considered a potent mitogen for mesangial cells and activates the classical mitogen-activated protein kinase (MAPK) cascade via S1P receptors. In this study, we show that S1P signalling is rapidly desensitized upon S1P receptor activation. A complete loss of S1P s...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1575433/ https://ncbi.nlm.nih.gov/pubmed/15466446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705980 |
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