Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity

BACKGROUND AND PURPOSE: Extracellular nucleotides act as potent mitogens for renal mesangial cells (MC). In this study we determined whether extracellular nucleotides trigger additional responses in MCs and the mechanisms involved. EXPERIMENTAL APPROACH: MC migration was measured after nucleotide st...

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Bibliographic Details
Main Authors: Klawitter, S, Hofmann, L P, Pfeilschifter, J, Huwiler, A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2007
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013899/
https://ncbi.nlm.nih.gov/pubmed/17200676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706983
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