New insights into the human 5-HT(4) receptor binding site: exploration of a hydrophobic pocket

1. A body of evidences suggests that a hydrophobic pocket of the human 5-HT(4) receptor contributes to the high affinity of some bulky 5-HT(4) ligands. A thorough study of this pocket was performed using mutagenesis and molecular modeling. 2. Ligand binding or competition studies with selected bulky...

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Detalhes bibliográficos
Main Authors: Rivail, Lucie, Giner, Mireille, Gastineau, Monique, Berthouze, Magali, Soulier, Jean-Louis, Fischmeister, Rodolphe, Lezoualc'h, Frank, Maigret, Bernard, Sicsic, Sames, Berque-Bestel, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575351/
https://ncbi.nlm.nih.gov/pubmed/15351779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705950
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