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New insights into the human 5-HT(4) receptor binding site: exploration of a hydrophobic pocket
1. A body of evidences suggests that a hydrophobic pocket of the human 5-HT(4) receptor contributes to the high affinity of some bulky 5-HT(4) ligands. A thorough study of this pocket was performed using mutagenesis and molecular modeling. 2. Ligand binding or competition studies with selected bulky...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1575351/ https://ncbi.nlm.nih.gov/pubmed/15351779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705950 |
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