Exploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modeling

1. Among the five human 5-HT(4) (h5-HT(4)) receptor isoforms, the h5-HT(4(a)) receptor was studied with a particular emphasis on the molecular interactions involved in ligand binding. For this purpose, we used site-directed mutagenesis of the transmembrane domain. Twelve mutants were constructed wit...

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Detalhes bibliográficos
Main Authors: Mialet, Jeanne, Dahmoune, Yamina, Lezoualc'h, Frank, Berque-Bestel, Isabelle, Eftekhari, Pierre, Hoebeke, Johan, Sicsic, Sames, Langlois, Michel, Fischmeister, Rodolphe
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572113/
https://ncbi.nlm.nih.gov/pubmed/10821780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703356
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