Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action

1. The topoisomerase II inhibitor amsacrine is used in the treatment of acute myelogenous leukemia. Although most anticancer drugs are believed not to cause acquired long QT syndrome (LQTS), concerns have been raised by reports of QT interval prolongation, ventricular fibrillation and death associat...

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Autores principales: Thomas, Dierk, Hammerling, Bettina C, Wu, Kezhong, Wimmer, Anna-Britt, Ficker, Eckhard K, Kirsch, Glenn E, Kochan, Mary C, Wible, Barbara A, Scholz, Eberhard P, Zitron, Edgar, Kathöfer, Sven, Kreye, Volker A W, Katus, Hugo A, Schoels, Wolfgang, Karle, Christoph A, Kiehn, Johann
Formato: Artigo
Lenguaje:Inglês
Publicado: 2004
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Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574964/
https://ncbi.nlm.nih.gov/pubmed/15148258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705795
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