Identification of a potent and highly efficacious, yet slowly desensitizing CB1 cannabinoid receptor agonist

1. The relationship of agonist efficacy to the rate of G protein-coupled receptor signaling desensitization is controversial. 2. Expressing inwardly rectifying potassium channels (GIRKs) in Xenopus oocytes, we have devised a signaling assay that clearly identifies CB1 cannabinoid receptor agonists w...

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Bibliographische Detailangaben
Hauptverfasser: Luk, Terry, Jin, Wenzhen, Zvonok, Alexander, Lu, Dai, Lin, Xin-Zhong, Chavkin, Charles, Makriyannis, Alexandros, Mackie, Ken
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2004
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574962/
https://ncbi.nlm.nih.gov/pubmed/15148260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705792
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