Markedly reduced effects of (−)-isoprenaline but not of (−)-CGP12177 and unchanged affinity of β-blockers at Gly389-β(1)-adrenoceptors compared to Arg389-β(1)-adrenoceptors

1. Substitution of arginine by glycine at position 389, a frequent β(1)-adrenoceptor polymorphism, reduces adenylyl cyclase stimulation by (−)-isoprenaline. β(1)-Adrenoceptors mediate the effects of catecholamines and nonconventional partial agonists ((−)-CGP12177) through different sites. We invest...

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Detaylı Bibliyografya
Asıl Yazarlar: Joseph, S S, Lynham, J A, Grace, A A, Colledge, W H, Kaumann, A J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2004
Konular:
Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574932/
https://ncbi.nlm.nih.gov/pubmed/15037517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705753
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