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Markedly reduced effects of (−)-isoprenaline but not of (−)-CGP12177 and unchanged affinity of β-blockers at Gly389-β(1)-adrenoceptors compared to Arg389-β(1)-adrenoceptors
1. Substitution of arginine by glycine at position 389, a frequent β(1)-adrenoceptor polymorphism, reduces adenylyl cyclase stimulation by (−)-isoprenaline. β(1)-Adrenoceptors mediate the effects of catecholamines and nonconventional partial agonists ((−)-CGP12177) through different sites. We invest...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1574932/ https://ncbi.nlm.nih.gov/pubmed/15037517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705753 |
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