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Different distribution of morphine and morphine-6β-glucuronide after intracerebroventricular injection in rats
1. We investigated the distribution of morphine and morphine-6β-glucuronide (M6G) in the brain and spinal cord after intracerebroventricular (i.c.v.) injection of each drug in rats. 2. The cerebrospinal fluid (CSF) concentration of M6G was 5–37 times greater than that of morphine 10, 60 and 120 min...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1574014/ https://ncbi.nlm.nih.gov/pubmed/12967951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705418 |
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