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Cardiac-specific overexpression of human β(2) adrenoceptors in mice exposes coupling to both G(s) and G(i) proteins
1. Left atrial strips from transgenic (TG4) mice with cardiac-specific overexpression (∼200-fold) of the β(2) adrenoceptor (β(2)AR) were isolated, and their isometric force of contraction (F(c)) in response to electrical stimulation was measured. 2. The βAR agonist isoprenaline elicited negative ino...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573787/ https://ncbi.nlm.nih.gov/pubmed/12711637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705191 |
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