Lack of Gα(i2) leads to dilative cardiomyopathy and increased mortality in β(1)-adrenoceptor overexpressing mice

AIMS: Inhibitory G (G(i)) proteins have been proposed to be cardioprotective. We investigated effects of Gα(i2) knockout on cardiac function and survival in a murine heart failure model of cardiac β(1)-adrenoceptor overexpression. METHODS AND RESULTS: β(1)-transgenic mice lacking Gα(i2) (β(1)-tg/Gα(...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Keller, Kirsten, Maass, Martina, Dizayee, Sara, Leiss, Veronika, Annala, Suvi, Köth, Jessica, Seemann, Wiebke K., Müller-Ehmsen, Jochen, Mohr, Klaus, Nürnberg, Bernd, Engelhardt, Stefan, Herzig, Stefan, Birnbaumer, Lutz, Matthes, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648201/
https://ncbi.nlm.nih.gov/pubmed/26464333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv235
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