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Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents

1. In an attempt to develop chelators as potent anti-tumour agents, we synthesized two series of novel ligands based on the very active 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) group. Since lipophilicity and membrane permeability play a critical role in Fe chelation efficacy, the aldeh...

Deskribapen osoa

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Xehetasun bibliografikoak
Egile Nagusiak: Becker, Erika M, Lovejoy, David B, Greer, Judith M, Watts, Ralph, Richardson, Des R
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2003
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573713/
https://ncbi.nlm.nih.gov/pubmed/12642383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705089
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