Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

BACKGROUND AND PURPOSE: The clinical utility of anthracycline antineoplastic drugs is limited by the risk of cardiotoxicity, which has been traditionally attributed to iron-mediated production of reactive oxygen species (ROS). EXPERIMENTAL APPROACH: The aims of this study were to examine the strongl...

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Autores principales: Šimůnek, T, Štěrba, M, Popelová, O, Kaiserová, H, Adamcová, M, Hroch, M, Hašková, P, Poňka, P, Geršl, V
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2008
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527851/
https://ncbi.nlm.nih.gov/pubmed/18536744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.236
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