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Identification of the di-pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti-tumour agents

1. In an attempt to develop chelators as potent anti-tumour agents, we synthesized two series of novel ligands based on the very active 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) group. Since lipophilicity and membrane permeability play a critical role in Fe chelation efficacy, the aldeh...

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Sonraí Bibleagrafaíochta
Main Authors: Becker, Erika M, Lovejoy, David B, Greer, Judith M, Watts, Ralph, Richardson, Des R
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573713/
https://ncbi.nlm.nih.gov/pubmed/12642383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705089
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