T cell selective apoptosis by a novel immunosuppressant, FTY720, is closely regulated with Bcl-2

1. A novel immunosuppressant FTY720 caused a significant decrease in peripheral T lymphocytes, but not in B lymphocytes upon oral administration. This decrease was mainly a result of FTY720-induced apoptosis. In this study, we confirmed FTY720-induced T cell selective apoptosis using lymphoma cell l...

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Bibliographic Details
Main Authors: Nagahara, Yukitoshi, Ikekita, Masahiko, Shinomiya, Takahisa
Format: Artigo
Language:Inglês
Published: 2002
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573588/
https://ncbi.nlm.nih.gov/pubmed/12429567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704970
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