An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFα up-regulates 5-HT(2A)-mediated contraction

1. Asthma research is arguably limited by an absence of appropriate animal models to study the pharmacology of inflammatory mediators that affect airway hyperresponsiveness and remodelling. Here we assessed an assay based on mouse tracheal segments cultured for 1–32 days, and investigated contractil...

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Main Authors: Adner, Mikael, Rose, Andrew C, Zhang, Yaping, Swärd, Karl, Benson, Mikael, Uddman, Rolf, Shankley, Nigel P, Cardell, Lars-Olaf
Formato: Artigo
Idioma:Inglês
Publicado: 2002
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573572/
https://ncbi.nlm.nih.gov/pubmed/12429569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704928
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