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An assay to evaluate the long-term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFα up-regulates 5-HT(2A)-mediated contraction

1. Asthma research is arguably limited by an absence of appropriate animal models to study the pharmacology of inflammatory mediators that affect airway hyperresponsiveness and remodelling. Here we assessed an assay based on mouse tracheal segments cultured for 1–32 days, and investigated contractil...

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Detaylı Bibliyografya
Asıl Yazarlar: Adner, Mikael, Rose, Andrew C, Zhang, Yaping, Swärd, Karl, Benson, Mikael, Uddman, Rolf, Shankley, Nigel P, Cardell, Lars-Olaf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2002
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573572/
https://ncbi.nlm.nih.gov/pubmed/12429569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704928
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