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Xestospongin C, a novel blocker of IP(3) receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells
1. We evaluated the role of the cross-linking of FcεRI-mediated inositol 1,4,5-triphosphate (IP(3)) in the increase in cytosolic Ca(2+) level ([Ca(2+)](i)) using xestospongin C, a selective membrane permeable blocker of IP(3) receptor, in RBL-2H3 mast cells. 2. In the cells sensitized with anti-dini...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1573325/ https://ncbi.nlm.nih.gov/pubmed/11959799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704662 |
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