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Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli

Proteinase-activated receptor-1 (PAR-1) is activated by thrombin and can be selectively activated by synthetic peptides (PAR-1-activating peptide: PAR-1-AP) corresponding to the receptor's tethered ligand. PAR-1 being expressed by afferent neurons, we investigated the effects of PAR-1 agonists...

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Bibliografische gegevens
Hoofdauteurs: Asfaha, Samuel, Brussee, Valentine, Chapman, Kevin, Zochodne, Douglas W, Vergnolle, Nathalie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2002
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573232/
https://ncbi.nlm.nih.gov/pubmed/11877315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704568
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