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Cyclosporin A-induced free radical generation is not mediated by cytochrome P-450

1. Reactive oxygen species (ROS) have been proposed to play a role in the side effects of the immunosuppressive drug cyclosporin A (CsA). 2. The aim of this study was to investigate whether cytochrome P-450 (CYP) dependent metabolism of CsA could be responsible for ROS generation since it has been s...

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Detalhes bibliográficos
Main Authors: Krauskopf, Alexandra, Buetler, Timo M, Nguyen, Nathalie S D, Macé, Katherine, Ruegg, Urs T
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573208/
https://ncbi.nlm.nih.gov/pubmed/11861326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704544
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