Antisense-induced down-regulation of thymidylate synthase and enhanced cytotoxicity of 5-FUdR in 5-FUdR-resistant HeLa cells

1. Thymidylate synthase (TS) is a target for several anticancer drugs. We previously showed that an antisense oligodeoxynucleotide (ODN) directed against TS mRNA down-regulated TS protein and enhanced cytotoxicity of TS-targeting drugs [including 5-fluorodeoxyuridine (5-FUdR)] in HeLa cells. Patient...

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Main Authors: Ferguson, Peter J, DeMoor, Janice M, Vincent, Mark D, Koropatnick, James
Formato: Artigo
Idioma:Inglês
Publicado: 2001
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1573083/
https://ncbi.nlm.nih.gov/pubmed/11724749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0704394
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