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MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells
BACKGROUND: Thymidylate synthase (TYMS) is an important folate-dependent enzyme in DNA synthesis and an important target for cancer chemotherapy. High TYMS expression levels in tumors are generally associated with resistance to 5-fluorouracil (5-FU). The cause of the variability in TYMS expression i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2013
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3750578/ https://ncbi.nlm.nih.gov/pubmed/23915286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-369 |
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