MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells

BACKGROUND: Thymidylate synthase (TYMS) is an important folate-dependent enzyme in DNA synthesis and an important target for cancer chemotherapy. High TYMS expression levels in tumors are generally associated with resistance to 5-fluorouracil (5-FU). The cause of the variability in TYMS expression i...

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Detaylı Bibliyografya
Asıl Yazarlar: Gotanda, Keisuke, Hirota, Takeshi, Matsumoto, Nozomi, Ieiri, Ichiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750578/
https://ncbi.nlm.nih.gov/pubmed/23915286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-369
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