Pancytopenia and Severe Gastrointestinal Toxicities Associated with 5-Fluorouracil in a Patient with Thymidylate Synthase (TYMS) Polymorphism

5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in solid tumors, including colon, gastric and breast cancers. The pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency leading to severe toxicity after administration of 5-flourouracil (5-FU) and c...

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發表在:Cureus
Main Authors: Wang, Bo, Walsh, Shannon J, Saif, Muhammad W
格式: Artigo
語言:Inglês
出版: Cureus 2016
主題:
Genetics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071174/
https://ncbi.nlm.nih.gov/pubmed/27774364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7759/cureus.798
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